Framework for dissection of complex cytonuclear epistasis by a two-dimensional genome scan

作     者：TANG ZaiXiang HU ZhiQiu YANG ZeFeng YU Bo XU ChenWu 

作者机构：Jiangsu Provincial Key Laboratory of Crop Genetics and Physiologyand Key Laboratory of Plant Functional Genomics of Ministry of EducationYangzhou UniversityYangzhou 225009China School of Public HealthMedical College of Soochow UniversitySuzhou 215123China Departments of Botany and Plant SciencesUniversity of CaliforniaRiversideCalifornia 92521USA 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：2012年第57卷第21期

页      面：2675-2680页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Basic Research Program of China(2011CB100106) the National Natural Science Foundation of China(30971846and31171187) the Vital Project of Natural Science of Universities in Jiangsu Province(09KJA210002) to C.Xu from the National Natural Science Foundation of China(31100882) to Z.Tang 

主　　题：基因组扫描 细胞核 二维 解剖 数量性状位点 框架 遗传结构 扫描策略 

摘      要：Epistasis between cytoplasmic and nuclear genes is the primary genetic component of complex quantitative *** dissection of cytonuclear epistasis is fundamentally important to understand the genetic architecture of complex *** this study,a two-dimensional genome scan strategy was employed to evaluate the contribution of cytoplasm,quantitative trait loci (QTL),QTL×QTL interactions and QTL×QTL×cytoplasm interactions to the phenotypic *** p-value and parameter value for each genetic effect were calculated by multiple regression analysis.A stepwise approach was suggested to build confidence in candidate QTL on the basis of q-value estimation,false discovery rate calculation and Bonferroni adjustment.A fine-scale grid scan strategy was proposed for further analysis of peaks of *** height in maize was used as an example to illustrate the efficiency of the two-dimensional genome scan strategy.