Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein
Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein作者机构：1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China 1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China 2Peopele s Hospital of Guangxi Zhuang Autonomous Region Nanning 530021 China 1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China 1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China 1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China 1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China 1State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai 200032 China
出 版 物：《Cell Research》 (细胞研究(英文版))
年 卷 期：2003年第13卷第2期
页 面：83-91页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
基 金：This work was supported by grants(G1998051004,and2002CB513100) 国家重点基础研究发展计划(973计划) grants(2001AA221141,2002BA711A02) 国家高技术研究发展计划(863计划)(toWXQIN)
主 题：IC53-2 CDK5 p35 hepatocellular carcinoma proliferation.
摘 要：We have identified IC53-2, a human homologue of the rat C53 gene from a human placenta cDNA library (GeneBank Accession ***217982). IC53-2 can bind to the CDK5 activator p35 by in vitro association assay. IC53-2 is mapped to human chromosome 17q21.31. The IC53-2 transcript is highly expressed in kidney, liver, skeletal muscle and placenta. It is abundantly expressed in SMMC-7721, C-33A, 3AO, A431 and MCF-7 cancer cell lines by RT-PCR assay. Stable transfection of IC53-2 cDNA into the hepatocellular carcinoma SMMC-7721 cell remarkably stimulates its growth in vitro. The above results indicate that IC53-2 is a novel human gene, which may be involved in the regulation of cell proliferation.
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