Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction
Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction作者机构:DepartmentofCardiologyFirstAffiliatedHospitalCollegeofMedicineZhejiangUniversityHangzhou310003China DepartmentofPhysiologyCollegeofMedicineZhejiangUniversityHangzhou310006China DepartmentofPhysiologytheUniversityofHongKongHongKongChina
出 版 物:《Journal of Zhejiang University Science》 (浙江大学学报(自然科学英文版))
年 卷 期:2004年第5卷第4期
页 面:494-498页
核心收录:
学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 0810[工学-信息与通信工程] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术(可授医学、理学学位)] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程(可授工学、理学学位)] 0812[工学-计算机科学与技术(可授工学、理学学位)] 10[医学]
摘 要:Objective:Myocardial infarction (MI) is the main cause of heart failure, but the relationship between the extent of MI and cardiac function has not been clearly *** present study was undertaken to investigate early changes in the electrocardiogram associated with infarct size and cardiac function after MI. Methods: MI was induced by ligating the left anterior descending coronary artery in rats. Electrocardiograms, echocardiographs and hemodynamic parameters were assessed and myocardial infarct size was measured from mid-transverse sections stained with Masson s trichrome. Results:The sum of pathological Q wave amplitudes was strongly correlated with myocardial infarct size (r=0.920, P0.0001), left ventricular ejection fraction (r=-0.868, P0.0001) and left ventricular end diastolic pressure (r=0.835, P0.0004).Furthermore, there was close relationship between MI size and cardiac function as assessed by left ventricular ejection fraction (r=-0.913, P0.0001) and left ventricular end diastolic pressure (r=0.893, P0.0001).Conclusion: The sum of pathological Q wave amplitudes after MI can be used to estimate the extent of MI as well as cardiac function.