Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction

作     者：陶则伟 黄元伟 夏强 傅军 赵志宏 陆贤 BRUCEI.C. 

作者机构：DepartmentofCardiologyFirstAffiliatedHospitalCollegeofMedicineZhejiangUniversityHangzhou310003China DepartmentofPhysiologyCollegeofMedicineZhejiangUniversityHangzhou310006China DepartmentofPhysiologytheUniversityofHongKongHongKongChina 

出 版 物：《Journal of Zhejiang University Science》 (浙江大学学报（自然科学英文版）)

年 卷 期：2004年第5卷第4期

页      面：494-498页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0810[工学-信息与通信工程] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

主　　题：心电图 心脏功能 心肌梗塞 MI 心力衰竭 

摘      要：Objective:Myocardial infarction (MI) is the main cause of heart failure, but the relationship between the extent of MI and cardiac function has not been clearly *** present study was undertaken to investigate early changes in the electrocardiogram associated with infarct size and cardiac function after MI. Methods: MI was induced by ligating the left anterior descending coronary artery in rats. Electrocardiograms, echocardiographs and hemodynamic parameters were assessed and myocardial infarct size was measured from mid-transverse sections stained with Masson s trichrome. Results:The sum of pathological Q wave amplitudes was strongly correlated with myocardial infarct size (r=0.920, P0.0001), left ventricular ejection fraction (r=-0.868, P0.0001) and left ventricular end diastolic pressure (r=0.835, P0.0004).Furthermore, there was close relationship between MI size and cardiac function as assessed by left ventricular ejection fraction (r=-0.913, P0.0001) and left ventricular end diastolic pressure (r=0.893, P0.0001).Conclusion: The sum of pathological Q wave amplitudes after MI can be used to estimate the extent of MI as well as cardiac function.