Influence of simvastatin on dopaminergic neurons of lipopolysaccharide—induced rat model of Parkinson's disease

作     者：Tan Wang Xue-Bin Cao Xiao-Wu Chen Pei-Pei Huang Tian Zhang Zhi-Bin Chen Bei-Sha Tang 

作者机构：Department of NeurologyXiangya HospitalCentral South University Department of NeurologyAffiliated Hospital of Hainan Medical College Department of NeurologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2015年第8卷第1期

页      面：64-67页

核心收录：

学科分类：1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by Provincial Natural Science Foundation of Hainan(Grant number 811214) Provincial Higher School Scientific Research Project of Hainan(Grant number Hjkj2011-35)was provided by Department of Neurology,Affiliated Hospital of Hainan Medical College 

主　　题：Parkinson’s disease Simvastatin Lipopolysaccharide astrocyte Tumor necrosis factor-alpha 

摘      要：Objective::To investigate the neuroprotective effects of simvastatin on lipopolysaccharide(LPS)-indueed rat model of Parkinson s disease(PD) and the mechanisms involved.Methods:Hemiparkinsonian rat models were induced by stereotaxieal injection of LPS in the right substantia nigra compacts.After 2 weeks of simvastatin treatment,rotational behavior test was performed after the intraperitoneal injection of apomorphine.Expression of tyroxine hydroxylase(TH) and glial fibrillan acidic protein were analyzed through immunohistochemical staining of substantia nigra and striatum,and the level of TNF-α was evaluated using enzyme-linked immunosorbent assay.Results:Comparing with untreated group,behavioral symptoms of the rats were significantly less in the rats that received simvastatin treatment.The TH positive cell count in substantia nigra and striatum were significantly increased(P0.05) and TNF- α expression was significantly decreased(P0.05) in simvastatin group compared to untreated group.Conclusions:Simvastatin could effectively inhibit the activation of astrocytes,reduce TNF-α expression,and exert anti-inflammatory effects,and thus protect the dopaminergic neurons in substantia nigra and striatum of the rat model of PD.