Resistin might not be a risk factor for carotid artery atherosclerosis in elderly Chinese males
Resistin might not be a risk factor for carotid artery atherosclerosis in elderly Chinese males作者机构：First Geriatric Cardiology Division Chinese PLA General Hospital 28 Fuxing Rd. Beijing 100853 China
出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)
年 卷 期：2014年第11卷第3期
页 面：222-228页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 08[工学]
基 金：supported by the Military Healthcare Fund Fund of the Ministry of Science and Technology of China
主 题：Resistin Intima media thickness Atherosclerosis The elderly
摘 要：Objective To investigate the correlation between the serum resistin level and carotid artery atherosclerosis in elderly Chinese males. Methods The study enrolled 235 elderly Chinese males [median age 76 （range 60-97） years] scheduled for ultrasound examination of carotid artery plaque and determination of carotid artery intima-media thickness （CIMT）. They were divided into carotid atherosclerotic plaque （CAP） and carotid atherosclerotic plaque-free （CAP-free） groups according to the ultrasound results. Their clinical profiles were col-lected, and the serum resistin and other blood biochemistry levels were *** The CAP group was older and had a thicker mean CIMT than the CAP-free group. However, there was no difference in the serum resistin level between the groups. CIMT was positively correlated with age （r = 0.299,P〈 0.001）. The serum resistin level was not correlated with CIMT, even after controlling for age. Multiple linear regression analysis revealed that age （β = 0.001,P〈 0.001） and body mass index （β = 0.002,P= 0.015） were significantly and posi-tively correlated with the mean CIMT. Only age [odds ratio （OR）： 1.159; 95% confidence interval （CI）： 1.078-1.183,P〈 0.001] was associ-ated with the presence of carotid artery atherosclerotic plaque. The serum resistin level was not correlated with the mean CIMT or associated with the presence of carotid artery atherosclerotic *** The results suggest that resistin might not be a risk factor for atherosclerosis in elderly Chinese males.
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