A practical synthesis of β-carbolines by tetra-n-butylammonium bromide (TBAB)-mediated cycloaromatization reaction of aldehydes with tryptophan derivatives

作     者：Zhen Wang Zhenzhen Yu Yao Yao Yakai Zhang Xuefeng Xiao Bin Wang 

作者机构：College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300353China Tianjin University of Traditional Chinese MedicineTianjin 300193China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第8期

页      面：1541-1544页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China (Nos. 21172120 and 21472093) Tianjin Municipal Science and Technology Commission (No. 14JCYBJC20600) for financial support 

主　　题：Carbolines Tryptophan Cycloaromatization TBAB Tetra-n-butylammonium bromide 

摘      要：A mild and efficient n Bu4 NBr-mediated oxidative cycloaromatization to prepareβ-carbolines from readily available tryptophans and aldehydes is *** reaction is practical and allows the synthesis ofβ-carbolines on *** of products crystallized from the reaction mixture and were easily removed by filtration,obviating the need for chromatographic separation.