出生于英国的亚裔婴儿对白喉、破伤风和B型流感嗜血杆菌常规免疫接种的免疫原性

作     者：Booy R. Haworth E.A. Ali K.A. 郭战宏 

作者机构：Research Centre for Child Health Luckes House Royal London Hospital Stepney Way London E1 1BB United Kingdom Prof. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第10期

页      面：17-17页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：常规免疫接种 免疫原性 流感嗜血杆菌 保护性抗体 伯克 抗体反应 几何平均滴度 年龄中位数 可信区间 队列研究 

摘      要：Aim: To determine the immunogenicity of routine vaccination against diphtheria , tetanus, and Haemophilus influenzae type b (Hib) in Asian infants born in the UK, and whether maternal antibody suppression occurs. Methods: A cohort study wi th 80%power, within 95%confidence limits, to show that 80%or fewer Asian infa nts would respond with an anti-PRP antibody concentration0.15 μg/ml. Infants of South Asian origin born in Berkshire were enrolled at two general practices i n Reading: 41 Asian families sequentially asked to participate within 2 weeks of birth; 36 infants were enrolled and 34 completed the study. Main outcome measur es were: antibody concentration against diphtheria, tetanus, and Hib expressed a s geometric mean titres (GMT) and proportion of infants about a threshold protec tive antibody concentration. Results: Median age for completing primary vaccinat ion course was 5 months. All 34 achieved anti-PRP antibody concentration of 0. 15 μg/ml, 33 were 1.0 μg/ml, and the GMT was 15.0 μg/ml. All infants develop ed protective antibody concentration 0.1 IU/ml for tetanus and diphtheria; the respective GMTs were 1.94 and 5.57 IU/ml. Infants with high (0.25 IU/ml) antibo dy concentrations against diphtheria and tetanus at 2 months achieved lower anti body concentrations after their three dose course than those with low concentrat ions ( 0.1 IU/ml) (p = 0.06 and 0.03, respectively). Conclusions: Despite evide nce for maternal antibody suppression of the response to tetanus and diphtheria vaccination, excellent antibody responses were achieved by routine vaccination a ccording to the accelerated schedule. High vaccine coverage should be encouraged to provide protection against the possibility of imported infection.