Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders

作     者：Rodrigo Pacheco 

作者机构：Departamento de Ciencias Biológicas Facultad de Ciencias de la Vida Universidad Andres Bello Laboratorio de Neuroinmunología Fundación Ciencia & Vida 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第12期

页      面：2091-2092页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by Programa de Apoyo a Centros con Financiamiento Basal AFB-170004(to Fundación Ciencia&Vida)from “Comisión Nacional de Investigación Científica y Tecnológica de Chile(CONICYT)” by grants FONDECYT-1170093 from Fondo Nacional de Desarrollo Científico y Tecnológico de Chile MJFF-10332.01 and MJFF-15076 from Michael J.Fox Foundation for Parkinson Research 

主　　题：Cross-talk T-cells neurodegenerative disorders 

摘      要：The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders: Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients, but also produces metabolites, fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells, which considerably affects the physiology of the host and contribute to maintaining homeostasis (Lyte, 2013).