Formins:Bringing new insights to the organization of actin cytoskeleton

作     者：GUO Chunqing REN Haiyun 

作者机构：Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education and College of Life Science Beijing Normal University Beijing 100875 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2006年第51卷第24期

页      面：2937-2943页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：This work was supported by the National Natural Science Foundation for Distinguished Young Scholars (Grant No. 30325005) the National Natural Science Foundation of China (Grant No. 30470176) the National Basic Research Program of China (Grant No. 2006CB 100100) 

主　　题：Formins蛋白 成蛋白 肌动蛋白 细胞骨架 肌动蛋白结合蛋白 

摘      要：The actin cytoskeleton is an important component of eukaryotic cell cytoskeleton and is temporally and spatially controlled by a series of actin binding proteins (ABPs). Among ABPs, formin family proteins have attracted much attention as they can nucleate unbranched actin filament from the profilin bound actin pool in vivo. In recent years, a number of formin family members from different organisms have been reported, and their characteristics are known more clearly, although some questions are still to be clarified. Here, we summarize the structures, func-tions and nucleation mechanisms of different formin family proteins, intending to compare them and give some new clues to the study of formins.