Protein Tyrosine Phosphatase 1B Inhibitory Potential in Erythroxylum monogynum Leaf Extracts
作者机构：Department of Pharmacology Jawaharlal Nehru Technological University-OTPRI Ananthapuramu-515001 AP India Department of Industrial Pharmacy Raghavendra Institute of Pharmaceutical Education and Research (RIPER) Ananthapuramu AP India Department of Pharmaceutics BalaJj ji College of Pharmacy Ananthapuramu AP India
出 版 物：《Asian Journal of Traditional Medicines》 (亚洲传统医药（英文）)
年 卷 期：2019年第14卷第2期
页 面：92-100页
学科分类：10[医学]
主 题：PTP 1B T2DM Erythroxylum monogynum goat liver skeletal muscle
摘 要：Insulin and Leptin resistance are the hallmarks for the development of type 2 diabetes mellitus (T2DM) and obesity. Both of these conditions are associated with increased activity and idiom of Protein Tyrosine Phosphatase 1B (PTP 1B). Therefore, inhibition of PTP 1B activity or down-regulation of its expression has become a striking area of therapeutics development in order to ameliorate the phenomenon of Insulin and Leptin resistance. Lack of awareness and late diagnosis makes diabetes difficult to manage. PTP 1B inhibitory activity by Erythroxylum monogynum plant extracts in the cytosolic supernatant of goat skeletal muscle and the liver was estimated. Erythroxylum monogynum plant extraction was done in hydroalcoholic solution (water–ethanol 20:80 (v/v)) and Methanol. The Polyphenols and protein content were identified in the hydroalcoholic and methanolic extracts. The greatest PTP 1B inhibitory activity in goat liver and skeletal muscle was found in the hydroalcoholic extract. Erythroxylum monogynum is a potent natural source of PTP 1B inhibition and may become cost-effective therapeutics in correcting metabolic disturbances of T2DM, obesity and cardiovascular disorders.
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