Influence of species,age and weight on the establishment of a murine model of brachial plexus root avulsion

作     者：Lifeng Yan Xiuchun Zhao Yaqiong Wang Lin Wang Xiao Cheng Lihua Zhou Xia Feng 

作者机构：Department of Human Anatomy Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 Guangdong Province China Department of Anesthesiology First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 Guangdong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第10期

页      面：764-768页

核心收录：

学科分类：10[医学] 

基　　金：a Grant from Health Department of Guangdong Province in China No. A2007169 

主　　题：brachial plexus root injury species age animal disease model modified surgery peripheral nerve injury neural regeneration 

摘      要：BACKGROUND： Animal models of brachial plexus root avulsion are required for the study of brachial plexus root injuries. The established ventral approach results in slight injuries, and is similar to mechanisms underlying human brachial plexus root ***： To analyze the effects of weight, age, and species on the success rate of brachial plexus root avulsion, and to determine the perfect method for establishing models of brachial plexus root ***, TIME AND SETTING： A randomized, block design was performed at the Laboratory of Professor Lihua Zhou, Zhongshan School of Medicine, Sun Yat-sen University, China from June 2008 to June ***： Sprague Dawley （SD） rats, golden hamsters, and BALb/C mice were used in the present ***： All animals were randomly subjected to classical brachial plexus root avulsion and modified brachial plexus root *** OUTCOME MEASURES： Success rate of brachial plexus root avulsion. RESULTS： The success rate of brachial plexus root avulsion was greater in the modified group than in the classical group （P〈0.01）. Moreover, the difference was significant in 15-day-old SD rats, 5-week-old SD rats, and 3-month-old BALb/C mice （P〈0.01）. The success rate of brachial plexus root avulsion was greater in the same weight, 15-day-old juvenile SD rats, than in the 3-month-old BALb/C mice （classical group, P〈0.01; modified group, P〈0.05）. The success rate of brachial plexus root avulsion was significantly greater in 3-month-old golden hamsters than in 5-week-old SD rats in the classical group （P〈0.05）. The success rate of brachial plexus root avulsion was significantly lower in the 15-day-old SD rats compared with the 5-week-old and 3-month-old SD rats in the classical group （P〈0.01）. However, there was no significant difference in the success rate of brachial plexus root avulsion between various ages of SD rats in the modified group （P〉0.05）.CONCLUSION： Modified surgery to induce brachial plexus root avulsion