Synthesis and Bioactivities Evaluation of Novel Anthranilic Diamides Containing N-(tert-Butyl)benzohydrazide Moiety as Potent Ryanodine Receptor Activator
作者机构：State Key Laboratory of Molecular Engineering of PolymersDepartment of Macromolecular ScienceFudan UniversitySonghu Road No.2005Shanghai 200438China State Key Laboratory of Elemento-Organic ChemistryInstitute of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityNo.94Weijin RoadNankai DistrictTianjin 300071China WuXi AppTec(Tian Jin) Co.Ltd.168 Nan Hai RoadTianjin 300457China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2019年第37卷第6期
页 面：605-610页
核心收录：
基 金：the NSFC/China (No.21502229) Tianjin Natural Science Foundation (No.16JCYBJC29400).
主 题：anthranilic diamides acylhydrazine heterocycles calcium channel structure-activity relationships insecticidal activities
摘 要：Anthranilic diamides have been proven to be a class of efficacious and safe insecticides targeting ryanodine receptors (RyRs) during the last decade. In order to develop innovative scaffolds with high insecticidal activity, two series of N-pyridylpyrazole derivatives containing N-(tert-butyl)benzohydrazide substructures were designed and synthesized. Their insecticidal activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) were evaluated. Preliminary bioassay results revealed that some of the new compounds exhibited good insecticidal activity against the oriental armyworm and diamondback moth. The mode of action of these compounds were verified using calcium-imaging technique and the results showed that some new compounds could effectively modulate the insect cytosolic Ca^2+ level, and break the cellular calcium homeostasis, indicating some of these compounds were potent activators of the RyRs.
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