Association between TSH Level and Pregnancy Outcomes in Euthyroid Women Undergoing IVF/ICSI:A Retrospective Study and Meta analysis
作者机构：Reproductive Medicine CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2019年第39卷第4期
页 面：631-637页
核心收录：
学科分类：10[医学]
基 金：This work was supported by grants from the National Key Research and Development Program of China (No.2018YFC1002103) the National Natural Science Foundation of China (No.81601348)
主 题：euthyroid pregnancy outcomes in vitro fertilization intra-cytoplasmic sperm injection
摘 要：The aim of this study was to determine the association between thyroid-stimulating hormone (TSH) level and pregnancy outcomes in euthyroid women undergoing in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI).A total of 1185 women were enrolled in the retrospective study,and 12 studies with a total of 6624 women were included in the meta-analysis (including the data of the present retrospective study).Participants in the retrospective study were divided into two groups in terms of their serum TSH levels:TSH 2.5 mIU/L group (h=355).They were monitored for the status of clinical pregnancy or *** the TSH 2.5 mIU/ L group,175 (49.3%) women achieved clinical pregnancy,while 21 (5.9%) had early pregnancy loss and 3 (0.8%) had ectopic *** significant differences were observed between the two groups in pregnancy outcomes (P=0.126,P=0.512,P=0.297).The meta-analysis also revealed no significant difference in the clinical pregnancy rate and the miscarriage rate between women with serum TSH 2.5 mIU/*** conclusion,high TSH levels (TSH level 2.5 mIU/L) did not affect clinical pregnancy rate or increase miscarriage rate in euthyroid women undergoing IVF/ICSI.
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