妊娠并发抗C型同种免疫的治疗

作     者：Hackney D.N. Knudtson E.J. Rossi K.Q. R.W.O'Shaug hnessy 郭慧芳 

作者机构：561Means Hall1654Up -ham DriveColumbusOH 43210-1282United States Dr.3 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第2期

页      面：59-59页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：同种免疫 血红蛋白水平 溶血性疾病 抗体滴度 疾病患儿 围生期 俄亥俄州立大学 致敏 

摘      要：OBJECTIVE:To review cases of anti -c isoimmunization and determine the most appropriate management ***:We performed a review of 102pregnancies managed at The Ohio State University from 1967to 2001for anti -c *** these,55had complete data and are included in this *** collected included serum titers,△OD 450 values,Liley zones,fetal and neonatal hemoglobin levels and a ntigen typing,neonatal direct antiglobulin test,and neonatal *** appropriateness of traditional management was then ***:Of the 55pregnan cies,46had fe-tuses with positive direct antiglob ulin test,and nine preg-nancies had unaffected *** t he affected neonates,12(26%)had serious hemolytic disease of the *** these 12,8required fetal transfu sion,and the remain-ing 4newborns had hemoglobin levels of less than 10g /dL at the time of delivery.A titer of 1:32or greater or the presence of hydrops fetalis identified all such *** were 58amniocenteses perform ed for△OD 450 .When plotted on modified Liley graph s,△OD 450 values corresponded to disease severity.T here were no perinatal deaths attributable to anti -c hemolytic disease of the ***:Anti -c isoimm unization might cause significant fetal and newborn hemolytic disease.A titer of 1:32or greater or evidence o f hydrops fetalis i-dentified all the serious hemolytic disease at our *** significance of antibody t iters and△OD 450 values was similar to Rh -D sensitize d pregnancies,and management by the same modalities is appropriate.