Copper ions influence the toxicity of β-amyloid(1-42) in a concen-tration-dependent manner in a Caenorhabditis elegans model of Alzheimer’s disease

作     者：LUO YunFeng ZHANG Jie LIU NianQing LUO Yuan ZHAO BaoLu 

作者机构：State Key Laboratory of Brain & Cognitive ScienceInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of SciencesBeijing 100049China Department of Cell Biology and NeuroscienceRutgers UniversityPiscatawayNJ 08854USA Synchrotron Radiation LaboratoryInstitute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Pharmaceutical SciencesUniversity of MarylandBaltimoreMD 21201USA 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2011年第54卷第6期

页      面：527-534页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：supported by the National Natural Science Foundation of China (Grant No. 30870578) the National Basic Research Program of China (Grant No. 2006CB500700) funded by the US National Institutes of Health for providing nematode strains used in this work 

主　　题：淀粉样蛋白 铜离子 浓度依赖性 老年痴呆症 毒性 模型 线虫 阿尔茨海默氏症 

摘      要：β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less *** the present study,we investigated the interaction and toxicity of Aβ1-42 and copper in the Aβ1-42 transgenic Caenorhabditis elegans worm model *** data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10-3 mol L-1 copper ***,the paralysis behavior was dramatically attenuated with exposure to 10-4 mol L-1 copper *** exogenous copper treatment also partially changed the homeostatic balance of zinc,manganese,and *** data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by Aβ and copper in *** ROS generation induced by Aβ and copper appear to be through sod-1,prdx-2,skn-1,hsp-60 and hsp-16.2 genes.