Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019

作     者：Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu 

作者机构：MOE Joint International Research Laboratory of Animal Health and Food SafetyEngineering Laboratory of Animal Immunity of Jiangsu ProvinceCollege of Veterinary MedicineNanjing Agricultural UniversityNanjing 210000China Key Laboratory of Animal Virology of Ministry of AgricultureZhejiang UniversityHangzhou 310058China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2019年第34卷第6期

页      面：601-609页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0906[农学-兽医学] 09[农学] 

基　　金：financially supported by the National Key Research and Development Program of China (2017YFD0500101) the Natural Science Foundation of Jiangsu Province (BK20170721) the China Association for Science and Technology Youth Talent Lift Project (2017-2019) 

主　　题：Pseudorabies virus (PRV) Glycoproteins Founder effect Epidemic Eastern China 

摘      要：Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig *** previously reported that variant PRV forms and recombination in China could be the source of continued ***,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of *** on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV *** addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 *** also found specific amino-acid changes and positively selected sites,possibly associated with functional *** analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV.