Inhibition of Pim-1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells
Inhibition of Pim-1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells作者机构：Department of Pathology & PathophysiologySchool of Basic Medicine ScienceGuangdong Medical College Hainan Provincial Key Laboratory of Tropical MedicineHainan Medical College
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2012年第5卷第8期
页 面：645-650页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from the Doctoral Program of Guangdong Medical College(B2010013) National Natural Science Foundation of China(81000073) Natural Foundation of Hainan Province of China 1811197, 310043,and 811201)
主 题：Nasopharyngeal carcinoma Pim-1 Quercetagetin Cell proliferation Cell migration
摘 要：Objective:To explore the role of proto-oncogene Pim-1 in the proliferation and migration of nasopharyngeal carcinoma(NPC) ***:Pim-1 expressions in NPC cell lines CNE1,CNE1-GL,CNE-2Z and C666-1 were examined by KT-PCR,western blotting and immunoflucesence,*** CNE1,CNE1-GL and C666-1 cells were treated with different concentrations of Pim-1 special inhibitor,quercelagetin,the cell viability,colony formation rate and migration ability were ***:Pim-1 expression was negative in well-differentiated CNE1 cells,whereas expressed weakly positive in poor-differentiated CNE-2Z cells and strongly positive in undifferentiated C666-1 ***,CNE1-GL cells that derived from CNE1 transfected with an Epstein Barr virus latent membrane protein-1 over-expression plasmid displayed stronger expression of *** of CNE1-GL and C666-1 cells with quercelagetin significantly decreased the cell viability,colony formation rate and migration ability but not the CNE1 ***:These findings suggest that Pim-1 overexpression contributes to NPC proliferation and migration,and targeting Pim-1 may be a potential treatment for anti-Pim-1-expressed NPCs.
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