Human umbilical cord-derived mesenchymal stem cells: Current trends and future perspectives
作者机构：Unit of Gynecology and ObstetricsDesenzano del Garda HospitalSection of GavardoGavardoBresciaItaly Department of Biomedicine and PreventionSection of Gynecology and ObstetricsUniversity of Rome Tor VergataRomeItaly Department of Obstetrics and GynecologyUniversity Medical Center LjubljanaLjubljanaSlovenia Gynecologic Oncology UnitDepartment of Experimental Clinical Oncology"Regina Elena"National Cancer InstituteRomeItaly Pineta Grande HospitalCastel VolturnoCasertaItaly Surgical Research LaboratoryMedical SchoolSaint Joseph UniversityDamas StreetBeirutLebanon Department of Obstetrics and GynaecologyLebanese American UniversityBeirutLebanon
出 版 物：《Asian pacific Journal of Reproduction》 (亚太生殖杂志（英文版）)
年 卷 期：2019年第8卷第3期
页 面：93-101页
学科分类：0710[理学-生物学] 1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 0901[农学-作物学] 100214[医学-肿瘤学] 0902[农学-园艺学] 10[医学]
主 题：Human umbilical cord stem cells Immunomodulation Cryopreservation Stem therapy
摘 要：Among resources of mesenchymal stem cells, human umbilical cord appears to be a rising source capable of differentiating into all germ layers, reaching and repairing lesion areas, and promoting wound repair, and it has also the capacity to influence the immune response. Human umbilical cord-derived mesenchymal stem cells are considered to be an optimal resource compared with other mesenchymal stem cells sources because they require a non-invasive recovery. All these characteristics allow their use in heterogeneous applications. Human umbilical cord-derived mesenchymal stem cells can regenerate tissues, stimulate angiogenesis, modulate inflammatory pathway signals and recruit endogenous stem cell. Human umbilical cord-derived mesenchymal stem cells suppress mitogen-induced signals and modulate the activation and proliferation of several immune cells, modifying lymphocyte phenotypes activity. In culture, human umbilical cord-derived mesenchymal stem cellss show the capacity to create several tissues such as bone, cartilage, and fat. Human umbilical cord-derived mesenchymal stem cells can be isolated from the different compartments of umbilical cord and processed by using different techniques. Clinical applications of human umbilical cord-derived mesenchymal stem cells include graft-versus-host disease, autoimmune diseases such as Sj?gren s syndrome and diabetes mellitus types 1 and 2, gynecological disorders like endometriosis. Recent studies have shown possible application on rheumatoid arthritis, osteoarthritis, and neuronal degenerative diseases. This review is focused on the resources, molecular profiles, propriety, in vitro characterizations, clinical applications and possible future usage of human umbilical cord-derived mesenchymal stem cells.
维普期刊数据库