儿童造血干细胞移植后的BK病毒感染1例

作     者：Benketira A. Tichit R. Tenenbaum J. F. Bernard 贺文龙 

作者机构：Hémato-Oncol.-Pédiat. Pédiatrie 3 Hpital Arnaud-de-Villeneuve avenue du Doyen-Gaston-Giraud 34295 Montpellier Cedex 05 France 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第11期

页      面：31-32页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：造血干细胞移植 BK病毒 病毒感染 同种异体移植术 多瘤病毒 泌尿系统症状 肺曲菌病 细胞病理学 聚合酶链反应 西多福韦 

摘      要：Polyomavirus hominis 1, better known as BK virus (BKV), infects up to 90%of the general population. Significant clinical manifestations can be seen in immunocompromised patients. We report a case of haemorragic cystitis likely due to BKV in a child after allotransplantation of hematopoietic stem cells. A 10-year old boy with poor-prognosis acute T lymphoblastic leukaemia underwent cord blood allogeneic stem cell transplantation while in his first relapse. Macroscopic haematuria and low back pain occurred by day 95, in the context of acute graft versus host disease and pulmonary aspergillosis. Histopathologic examination showed a cytopathogenetic effect consistent with the diagnosis of BKV infection. Urinary PCR was positive for BKV. Treatment with cidofovir was followed by a marked improvement of urinary symptoms. The current understanding, diagnosis, and treatment of BKV-associated infection is discussed.