Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene

作     者：ZHOU Zhen-Zhen ZHU Hong-Jie YANG Cheng-Long LIU Yan-Jun JIANG Nan XIAO Yong-Sheng SHI Li-Yun JIAO Rui-Hua GE Hui-Ming TAN Ren-Xiang 

作者机构：State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecules Nanjing University State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine School of Pharmacy Nanjing Medical University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2019年第17卷第5期

页      面：387-393页

核心收录：

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.21672101 21702099 and 81673333) 

主　　题：Daldinia eschscholzii Global regulator Cyclopentenone 

摘      要：Replacement of the native promoter of the global regulator Lae A-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher s reaction, and electronic circular dichroism(ECD). Dalestones A and B inhibit the gene expression of TNF-α and IL-6 in LPS-induced RAW264.7 macrophages.