Metabolic disorder in the progression of heart failure

作     者：Xiuxiu Zhang Huiying Liu Juan Gao Min Zhu Yupeng Wang Changtao Jiang Ming Xu 

作者机构：Department of Cardiology and Institute of Vascular MedicinePeking University Third Hospital/ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Department of Physiology and PathophysiologySchool of Basic Medical SciencesPeking UniversityKey Laboratory of Molecular Cardiovascular ScienceMinistry of Education and Beijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2019年第62卷第9期

页      面：1153-1167页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by the National Natural Science Foundation of China (81625001, 81700010) National Key Research & Development Program of China (2018YFC1312700, 2018YFC1312701) 

主　　题：heart failure metabolomics TAC HF stages A–C biomarker pathway analysis 

摘      要：Heart failure(HF) is a major clinical concern owing to its high prevalence and high ***,an effective approach to predict diagnostic biomarkers and to explore the altered metabolic pathways in pathogenesis,has been extensively applied in evaluating the course of *** this study,we used this approach to analyse the abundance of metabolites,with liquid chromatograph-mass spectrometer,in plasma samples from rats with transverse aortic constriction(TAC) and patients at different stages of *** compared the metabolic parameters within and between TAC rats and *** apparent metabolic shift was observed in rats,from compensated hypertrophy stage to decompensated hypertrophy stage,and in patients with HF,from stage A to stage B and subsequently stage *** biomarkers were predicted by comparing the variable importance in the projection scores and fold change analysis within and between rats and *** pathway analysis and network analysis provided an overview of the largely disturbed metabolic pathways,and those interfered at different stages and across species were *** significantly changed metabolites and pathways revealed the underlying mechanisms of HF pathogenesis,hinted at novel potential biomarkers,and provided potential therapeutic intervention targets for HF.