IgG4-related autoimmune pancreatitis overlapping with Mikulicz's disease and lymphadenitis:A case report

作     者：Li-Mei Qu Ya-Hui Liu David R Brigstock Xiao-Yu Wen Yong-Fang Liu Ya-Jun Li Run-Ping Gao 

作者机构：Department of Hepatic-Biliary-Pancreatic MedicineFirst Hospital Jilin University Department of Hepatic-Biliary-Pancreatic SurgeryFirst Hospital Jilin University The Research Institute at Nationwide Children’s Hospital Columbus OH 43205 United States Division of Pediatric Surgery Department of Surgery The Ohio State University Columbus OH 43205United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第48期

页      面：9490-9494页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Scientific Foundation No.81070370 81270544(to Gao RP)and NIH 5R01AA016003(to Brigstock D) 

主　　题：IgG4-related disease Type 1 autoimmune pancreatitis Mikulicz’s disease Lymphadenitis 

摘      要：Autoimmune pancreatitis(AIP)is a form of chronic pancreatitis that is categorized as type 1 or type 2according to the clinical *** 1 AIP,which predominantly presents in a few Asian countries,is a hyper-IgG4-related *** report a case of IgG4-related AIP overlapping with Mikulicz’s disease and lymphadenitis,which is rare and seldom reported in literature.A 63-year male from Northeast China was admitted for abdominal distension lasting for one *** presented symmetric swelling of the parotid and submandibular glands with slight dysfunction of salivary secretion for 6 *** had a 2-year history of bilateral submandibular lymphadenopathy without *** underwent surgical excision of the right submandibular lymph node one year prior to *** denied any history of alcohol,tobacco,or illicit drug *** examination revealed high fasting blood sugar level(8.8 mmol/L)and high level of IgG4(15.2 g/L).Anti-SSA or anti-SSB were *** tomography of the abdomen showed a diffusely enlarged pancreas with loss of *** stain for IgG4 demonstrated diffuse infiltration of IgG4-positive plasma cells in labial salivary gland and lymph node biopsy *** patient received a dose of 30 mg/d of prednisone for three *** this three-week follow-up,the patient reported no discomfort and his swollen salivary glands,neck lymph node and pancreas had returned to normal *** patient received a maintenance dose of 10mg/d of prednisone for 6 mo,after which his illness had not recurred.