Usefulness of upright T wave in lead aVR for predicting short-term prognosis of patients with ischemic stroke

作     者：Hong-Jie Yang Xin Liu Chuan Qu Shao-Bo Shi Bo Yang Yang Hong-Jie;Liu Xin;Qu Chuan;Shi Shao-Bo;Yang Bo

作者机构：Department of CardiologyRenmin Hospital of Wuhan UniversityHubei Key Laboratory of CardiologyCardiovascular Research InstituteWuhan 430060China 

出 版 物：《Chronic Diseases and Translational Medicine》 (慢性疾病与转化医学（英文版）)

年 卷 期：2018年第4卷第3期

页      面：192-198页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by grant 2014CFA061 from the Key Foundation of Hubei Province of China 

主　　题：T wave in lead aVR Ischemic stroke Prognosis 

摘      要：Background: Upright T wave in lead aVR (TaVR) has recently been reported to be associated with cardiovascular death and mortality in general population and in patients with prior cardiovascular disease (CVD). However, the evidence for the predictive ability of TaVR in patients with ischemic stroke (IS) is lacking. Methods: A total of 625 consecutive patients with IS (mean age:66 ± 12 years;379 male) were enrolled in this study between January 2013 and December 2014. Patients were divided into upright TaVR (≥0 mV;n = 201) and negative TaVR (450 ms, higher rate of negative T in lead II, higher rate of negative T in lead V6, higher rate of ST depression, and longer QTc duration. During the mean follow-up period of 20.0 ± 5.8 months, 29 (4.6%) patients experienced all-cause death and 12 (1.9%) patients experienced cardiovascular death, the primary end point. Concomitantly, 94 (15%) patients experienced recurrence of IS, the secondary end point. After adjusting for clinical covariates, upright TaVR was independently associated with all-cause death [hazard ratio (HR): 2.88, 95%confidence intervals (CI): 1.07-7.73], cardiovascular death (HR: 3.04, 95% CI:1.07-8.64), and IS recurrence (HR:1.86, 95%CI:1.08-3.20). Conclusions: Upright TaVR in patients with IS is associated with increased mortality and recurrence of IS.