酒精是意大利北部丙型肝炎患者发生肝细胞脂肪变性和肝纤维化的重要协同因素

作     者：Fabris P. Floreani A. Carlotto A. 黎一兵 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第2期

页      面：59-59页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：丙型肝炎患者 肝细胞脂肪变性 肝纤维化 意大利北部 慢性丙型肝炎 肝脂肪变性 宿主因素 病毒学检查 饮酒量 实验室分析 

摘      要：Steatosis in patients with chronic hepatitis C (CHC) may be the result of both viral and host factors. To evaluate: (1) the relationship between steatosis and either host or viral factors; (2) the correlation between steatosis and fibrosi s in patientswith CHC. A consecutive series of 349 patients were evaluated for s teatosis. At liver biopsy, patients were tested for virological, and laboratory analysis and questioned for alcohol consumption. Logistic regression analysis de monstrated that steatosis was independently associated with genotype 3a (odds ra tio, OR 3.5), alcohol intake at the time of biopsy (OR 2.6) and age 35 years (O R 2.7). In multivariate analysis the presence of fibrosis was associated with pa st alcohol abuse (OR 3.7), and age older than 44 years (OR 2.2). Overall, a weak correlation was found between grade of steatosis and fibrosis score (r=0.861, P =0.05), which disappeared excluding patients without past or current alcohol int ake. A direct correlation emerged between grade of steatosis and both ‘grading ’and ‘staging’only in patients with genotypes other than 3a. Genotype 3a is t hemain risk factor for steatosis in patientswith CHC. The grade of steatosis cor related with both grading and staging only in patients with genotypes other than 3a and this relationship is strictly linked to alcohol consumption.