Cyclic mechanical stretch regulates MMPs and TIMPs expression in corneal fibroblasts

作     者：Chengxing Liu Pengfei Feng Xiaona Li Xiaojun Wang Weiyi Chen 

作者机构：Institute of Applied Mechanics and Biomedical EngineeringTaiyuan University of Technology 

出 版 物：《医用生物力学》 (Journal of Medical Biomechanics)

年 卷 期：2013年第28卷第S1期

页      面：7-8页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(11032008) Natural Science Foundation of Shanxi Province(2012011046-2) 

主　　题：corneal keratomileusis ablation intraocular stretch altered refractive diverse TIMPs mechanically 

摘      要：Laser in situ keratomileusis(LASIK)is a relatively new ophthalmic procedure in refractive surgery.It involves the use of a microkeratome to create a thin corneal flap followed by excimer laser ablation of the corneal stroma and repositioning of the flap.However,complications are bound to occur when a surgical procedure is performed with increasing frequency.In some cases,serious complications such as keratectasia occurred.Risk factors for corneal keratectasia include a thin cornea at baseline,thick corneal flap,excessive ablation,irregular corneal thickness,diverse ablation rates,preexisting keratoconus or form fruste keratoconus,and high intraocular pressure(IOP)~[1].It is evident from incisional refractive surgery that the cornea is not mechanically inert.The mechanical environment of the central corneal tissue is also altered un-