Adipose-derived stromal/stem cells from different adipose depots in obesity development

作     者：Karina Ribeiro Silva Leandra Santos Baptista 

作者机构：Laboratory of Tissue Bioengineering Directory of Metrology Applied to Life Sciences National Institute of Metrology Quality and Technology Post-Graduation Program of BiotechnologyNational Institute of Metrology Quality and Technology Multidisciplinary Center for Biological Research (Numpex-Bio)Federal University of Rio de Janeiro Campus Duque de Caxias 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第3期

页      面：147-166页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：the National Council for Scientific and Technological Development (CNPq) the Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) the Coordination of High Education Personnel Improvement (CAPES) for financial support 

主　　题：White adipose tissue Metabolic diseases Obesity Adipose-derived 

摘      要：The increasing prevalence of obesity is alarming because it is a risk factor for cardiovascular and metabolic diseases(such as type 2 diabetes). The occurrence of these comorbidities in obese patients can arise from white adipose tissue(WAT) dysfunctions, which affect metabolism, insulin sensitivity and promote local and systemic inflammation. In mammals, WAT depots at different anatomical locations(subcutaneous, preperitoneal and visceral) are highly heterogeneous in their morpho-phenotypic profiles and contribute differently to homeostasis and obesity development, depending on their ability to trigger and modulate WAT inflammation. This heterogeneity is likely due to the differential behavior of cells from each depot. Numerous studies suggest that adiposederived stem/stromal cells(ASC; referred to as adipose progenitor cells, in vivo)with depot-specific gene expression profiles and adipogenic and immunomodulatory potentials are keys for the establishment of the morphofunctional heterogeneity between WAT depots, as well as for the development of depot-specific responses to metabolic challenges. In this review, we discuss depot-specific ASC properties and how they can contribute to the pathophysiology of obesity and metabolic disorders, to provide guidance for researchers and clinicians in the development of ASC-based therapeutic approaches.