Ureteral stent technology:Drug-eluting stents and stent coatings

作     者：Luo Yang Samantha Whiteside Peter A.Cadieux John D.Denstedt 

作者机构：Department of SurgeryDivision of UrologyNo.4 West China HospitalSichuan UniversityChengduSichuanChina Department of Urology of West China Hospital of Sichuan UniversityChengduSichuanChina Department of SurgeryDivision of UrologyWestern UniversityLondonOntarioCanada Department of Microbiology and ImmunologyWestern UniversityLondonOntarioCanada School of Health SciencesFanshawe CollegeLondonOntarioCanada 

出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)

年 卷 期：2015年第2卷第4期

页      面：194-201页

学科分类：1002[医学-临床医学] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

主　　题：Drug-eluting stents Stent coatings Urinary infection 

摘      要：Ureteral stents are commonly used following urological procedures to maintain ureteral ***,alongside the benefits of the device,indwelling stents frequently cause significant patient discomfort(pain,urgency,frequency)and can become encrusted and *** importance of these sequelae is that they are not only bothersome to the patient but can lead to significant morbidity,urinary retention,ureteral damage,recurrent infections,pyelonephritis and *** these problems occur,stent removal or replacement alongside antibiotic,analgesic and/or other symptom-modifying therapies are essential to successfully treat the *** an attempt to prevent such morbidity,numerous approaches have been investigated over the past several decades to modify the stent itself,thereby affecting changes locally within the urinary tract without significant systemic *** strategies include changes to device design,polymeric composition,drug-elution and surface *** these,drug-elution and surface coatings are the most studied and display the most promise for advancing ureteral stent use and *** article reviews these two strategies in detail to determine their clinical potential and guide future research in the area.