Effect of uncontrolled hyperglycemia on levels of adhesion molecules in patients with diabetes mellitus type 2

作     者：Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Zofia RUPRECHT Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta RO 

作者机构：Department of Pathophysiology Faculty of Pharmacy Nicolaus Copernicus University in ToruńCollegium Medicum in Bydgoszcz Department of Endocrinology and Diabetology Faculty of Medicine Nicolaus Copernicus University in ToruńCollegium Medicum in Bydgoszcz 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2015年第16卷第5期

页      面：355-361页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Project supported by the Nicolaus Copernicus University Collegium Medicum in Bydgoszcz Poland 

主　　题：Diabetic kidney disease Glomerular filtration rate Hyperfiltration 

摘      要：Objective： Uncontrol ed diabetes has become a major cause of mortality and morbidity by reason of vascular angiopathy. The aim of this study was to evaluate the concentrations of soluble forms of vascular adhesion molecule-1 （sVCAM-1）, intercel ular adhesion molecule-1 （sICAM-1）, E-selectin, and thrombomodulin in patients with wel-control ed and uncontrol ed diabetes type 2. Methods： The study was conducted on 62 patients with diabetes. Group I consisted of 35 patients with wel-control ed diabetes. The second group included 27 patients with uncontrol ed diabetes with micro-albuminuria. A control group was made up of 25 healthy volunteers. The concentrations of sVCAM-1, sICAM-1, sE-selectin, and soluble thrombomodulin were assayed in plasma. Serum concentration of cre-atinine was measured and the plasma concentrations of fasting glucose and glycated hemoglobin （HbA1c） determined. Results： Lower concentrations of ICAM-1 were found in the group of uncontrolled diabetes patients compared with those with wel-control ed disease. In patients with uncontrol ed diabetes, VCAM-1 levels were significantly higher compared with the group with wel-control ed diabetes. In patients with uncontrol ed diabetes a positive correlation was obtained between glomerular filtration rate and sE-selectin and a negative correlation between the levels of creatinine and ICAM-1, although there was a positive correlation between （HbA1c） and ICAM-1. Conclusions： The study con-firmed the participation of the inflammatory process associated with impaired vascular endothelial function in the pathogenesis of type 2 diabetes. The opposite effect of uncontrolled hyperglycemia on adhesion molecules suggests different functions of VCAM-1 and ICAM-1 in complications of diabetes.