Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy

作     者：Yuanwen Zou Wei Zhang Hongqiao Zhou Changhui Fu Longfei Tan Zhongbing Huang Xiangling Ren Jun Ren Xudong Chen Xianwei Meng 

作者机构：College of Materials Science and Engineering Sichuan University Second Clinical Medical College of Jinan University Shenzhen People's Hospital Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences (CAS) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第2期

页      面：481-484页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：financial support from the National Science Foundation of China(Nos. 61671435 and 81630053) Beijing Natural Science Foundation(No. 4161003) 

主　　题：Microwave thermal therapy Zirconium metal-organic framework nanocubes Microwave sensitizer Tumor therapy Biosafety 

摘      要：Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.