Value of superb micro-vascular imaging in predicting ischemic stroke in patients with carotid atherosclerotic plaques

作     者：De-Bin Yang Jie Zhou Lan Feng Rong Xu Ying-Chun Wang 

作者机构：Department of Ultrasonic ImagingJiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2019年第7卷第7期

页      面：839-848页

核心收录：

学科分类：10[医学] 

基　　金：Supported by Shanghai Jiading District Health and Family Planning Commission Health Planning Commission Scientific Research Project No.KYXM 2015-KY-02 

主　　题：Superb micro-vascular imaging Contrast-enhanced ultrasound Carotid atherosclerotic plaques Ischemic stroke 

摘      要：BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic ***-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening for unstable plaque. The emergence of superb micro-vascular imaging(SMI) offers the possibility of clinically screening for unstable plaque AIM To investigate the value of SMI in predicting ischemic stroke in patients with carotid atherosclerotic *** Patients with carotid atherosclerotic plaques(luminal stenosis of 50%-70%) were enrolled into the present study. All patients received conservative *** patient s clinical baseline data, serological data, CEUS and SMI data were analyzed. All patients underwent a 3-year follow-up. The follow-up endpoint was the occurrence of ischemic stroke and patients were divided into stroke group and non-stroke group according to whether the prognosis occurred or ***, the difference in clinical data was compared, the correlation of SMI and CEUS was analyzed, and multiple Cox regression and receiver operating characteristic curve were applied to investigate the value of SMI and CEUS in predicting cerebral arterial thrombosis in three *** In this study, 43 patients were enrolled in the stroke group and 82 patients were enrolled in the non-stroke group. Cox regression revealed that SMI level(P =0.013) and enhancement intensity(P = 0.032) were the independent factors influencing ischemic stroke. There was a positive correlation between SMI level and enhancement intensity(r = 0.737, P = 0.000). The area under curve of SMI level predicting ischemic stroke was 0.878. The best diagnostic point was ≥ level Ⅱ, and its sensitivity and specificity was 86.05% and 79.27%. The area under curve of enhancement intensity predicting ischemic stroke was 0.890. The best diagnostic point was 9.92 db, and its sensitivity and specificity was 88.37% and89.02%. As the SMI level gradually increased, the