Overview of the reporter genes and reporter mouse models

作     者：Shun Li Li-xiang Chen Xiu-hua Peng Chao Wang Bo-yin Qin Dan Tan Cheng-xiao Han Hua Yang Xiao-nan Ren Fang Liu Chun-hua Xu Xiao-hui Zhou 

作者机构：Key Laboratory of Medical Molecular Virology Shanghai Public Health Clinical Center Ministry of Education and HealthFudan University School of Agriculture and BiologyShanghai Jiao Tong University 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2018年第1卷第1期

页      面：29-35页

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Shanghai Municipal Health and Family Planning Commission Scientific Research Project,Grant/Award Number:20154Y0075 Shanghai Municipal Fund for Science and Technology Development,Grant/Award Number:15140904000 Shanghai Public Health Clinical Center,Grant/Award Number:KY-GW-2017-04,KY-GW-2018-48 National Natural Science Foundation of China,Grant/Award Number:31270217,31601908,81471397 

主　　题：Cre reporter strains random reporter strains reporter genes ROSA26 reporter strains 

摘      要：Reporter genes are widely applied in biotechnology and biomedical research owning to their easy observation and lack of toxicity. Taking advantage of the reporter genes in conjunction with imaging technologies, a large number of reporter mouse models have been generated. Reporter mouse models provide systems that enable the studies of live cell imaging, cell lineage tracing, immunological research and cancers etc. in vivo. In this review, we describe the types of different reporter genes and reporter mouse models including, random reporter strains, Cre reporter strains and ROSA26 reporter strains. Collectively, these reporter mouse models have broadened scientific inquires and provided potential strategies for generation of novel reporter animal models with enhanced capabilities.