Biogenesis of Mammalian MicroRNAs:A Global View
Biogenesis of Mammalian MicroRNAs:A Global View作者机构:Department of Radiation Oncology New York Methodist Hospital Weill Cornell Medical College Brooklyn NY 11215 USA Department of Pharmacology Masonic Cancer Center University of Minnesota Minneapolis MN 55455 USA
出 版 物:《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报(英文版))
年 卷 期:2012年第10卷第5期
页 面:239-245页
核心收录:
学科分类:0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 090501[农学-动物遗传育种与繁殖]
基 金:the support of the American Heart Association(Grant No. 0835471N)
主 题:MicroRNA expression MicroRNA processing Primary microRNA Drosha
摘 要:MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes, miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article reviews our current knowledge of the mechanism and regulation of mammalian miRNA expression and points out areas of research that may enhance our understanding of how the specificity and efficiency of miRNA pro- duction is controlled in vivo.