Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain

作     者：Li Qiang Fu Chen Yu Ling Xing Sheng Guo Hui Li He Yu She Yang 

作者机构：Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2012年第23卷第1期

页      面：9-12页

核心收录：

学科分类：090603[农学-临床兽医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：National Science and Technology Major Project for the support of this research supported by Key New Drug Creation and Manufacturing Program,China(No:2009ZX09301-001) 

主　　题：Synthesis Pleuromutilin Novel side chains Antibacterial activity 

摘      要：In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance,a series of pleuromutilin derivatives with novel C（14） side chain were synthesized and evaluated for their in vitro antibacterial *** results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram-positive *** particular,compound lOd exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid,emerged as potential molecule for further investigation.