New ent-kaurane diterpenes with chiral epoxyangelate moieties from Wedelia prostrata

作     者：Zhongnan Wu Yubo Zhang Wen Li Nenghua Chen Qianwen Niu Yingying Li Qingguo Li Dan Yang Yaolan Li Guocai Wang 

作者机构：Institute of Traditional Chinese Medicine ξ Natural Products College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan University Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan University School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine Department of Specific Diagnosis The 324th Military Hospital 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第2期

页      面：451-453页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81473116,81673319,81673670) Science and Technology Planning Project of Guangdong Province (Nos. 2016A030303011, 2016B030301004) Natural Science Foundation of Guangdong Province(No. 2017A030313732) China Postdoctoral Science Foundation(No. 55350202) Natural Science Foundation of Chongqing(No. cstc2013jcyjA10065) 

主　　题：Wedelia prostrata Chiral epoxyangelate moieties Ent-kaurane diterpenes Absolute configuration Cytotoxicity activities 

摘      要：Four new ent-kaurane diterpenes with chiral epoxyangelate moieties, (2′R,3′R)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (1), (2′S,3′S)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (2), (2′S,3′R)-3 a- (2 ,3 -epoxyangeloyloxy)-kaur-16-en-19-oic acid (3) and (2′R,3′S)-3α- (2′,3 -epoxyangeloyloxy)-kaur-16-en-19-oic acid (4), along with eight known diterpenes (5-12), were isolated from Wedelia prostrata. The absolute configurations of the new structures were determined by X-ray crystallography,ECD calculations and chemical methods. All compounds were evaluated for their cytotoxicity activities on human HepG-2 cells,with IC_(50) values of 11.72 ±0.22 μmol/L to 54.75±1.12 μmol/L.