The hepatic sinusoidal endothelial lining and colorectal liver metastases
The hepatic sinusoidal endothelial lining and colorectal liver metastases作者机构：Australian Key Centre for Microscopy and Microanalysis Electron Microscopy Unit The University of Sydney NSW 2006 Australia Department of Pathology The Jikei University School of Medicine Tokyo Japan Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine Tokyo Japan Department of Laboratory Medicine The Jikei University School of Medicine Tokyo Japan
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2007年第13卷第6期
页 面：821-825页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the Japan Association for the Advancement of Medical Equipment(H17-nano-013 141)
主 题：Apoptosis Australia Correlative microscopy Endothelial cells Hepatic metastasis Colorectal cancer CC531 Gaps Interferon gamma Kupffer cells Natural killer cells Nitric oxide Macrophages Modeling Phagocytosis Plugging Pit cells Stellate cells X-ray micro-computed tomography
摘 要：Colorectal cancer (CRC) is a common malignant disease and the severe nature of cases in men and women who develop colorectal cancer makes this an important socio-economic health issue. Major challenges such as understanding and modeling colorectal cancer pathways rely on our understanding of simple models such as outlined in this paper. We discuss that the development of novel standardized approaches of multidimensional (correlative) biomolecular microscopy methods facilitates the collection of (sub) cellular tissue information in the early onset of colorectal liver metastasis and that this approach will be crucial in designing new effective strategies for CRC treatment. The application of X-ray micro-computed tomography and its potential in correlative imaging of the liver vasculature will be discussed.
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