Effect of tanshinone on blood coagulation, inflammatory factors and immune function in children with allergic purpura
作者机构：Department of PaediatricsChengdu Fifth People's HospitalChengdu611130Sichuan ProvinceChina
出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)
年 卷 期：2019年第25卷第4期
页 面：38-41页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Science Research Fund of Chengdu Health Bureau. Project No.: 2012007
主 题：Tanshinone Children with allergic purpura Coagulation inflammatory factors Immune function
摘 要：Objective:To investigate the effects of tanshinone treatment on coagulation function, inflammatory factors and immune function in children with allergic purpura, and to guide clinical ***:130 children with allergic purpura diagnosed in a certain hospital from November 2015 to June 1818 were selected. According to the random number table method, they were divided into control group and study group, 65 cases in each group. The control group was given conventional anti-allergic drugs, and the study group was treated with tanshinone on the basis of the control group. The changes of renal function, inflammatory factors, coagulation function and immune function were compared between the two groups before and after ***:There were no significant differences in renal function, inflammatory factors, coagulation function and immune function between the two groups (P0.05). After treatment, the levels of renal function Scr, BUN and Cysc and were significantly decreased in the two groups, and the inflammatory factors PCT, CRP levels were significantly decreased in the two groups (P0.05). The above indexes of the study group were significantly lower than the control group (P0.05). After treatment, APTT and PT levels were significantly increased in both groups, and FIB and ESR levels were significantly lower (P0.05). The levels of APTT and PT in the study group were significantly higher than those in the control group, and the FIB and ESR level was significantly lower than that in the control group (P0.05). After treatment, the levels of IgG, C3 and C4 were significantly lower in the two groups (P0.05). The levels of IgG, C3 and C4 in the study group were significantly lower than those in the control group (P0.05).Conclusion: Tanshinone combined with anti-allergic drugs has significant curative effects on children with Henoch-Schonlein purpura. It can significantly reduce renal function damage, alleviate inflammation stress response, improve coagu
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