Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient:A case report

作     者：Katerina G Oikonomou Dost Sarpel Alexandra Abrams-Downey Adnan Mubasher Douglas T Dieterich 

作者机构：Division of Infectious DiseasesIcahn School of Medicine at Mount Sinai Department of PathologyIcahn School of Medicine at Mount Sinai Division of Liver DiseasesIcahn School of Medicine at Mount Sinai 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第2期

页      面：226-233页

学科分类：10[医学] 

主　　题：Necrolytic acral erythema Human immunodeficiency virus Hepatitis C virus Zinc deficiency Case report 

摘      要：BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc *** is characterized by erythematous or violaceous lesions occurring primarily in the lower *** treatment includes systemic steroids and oral zinc *** report a case of NAE in a 66-year-old human immunodeficiency virus(HIV)/HCV co-infected woman with *** is rarely reported in co-infected patients and the exact mechanisms of pathogenesis are still *** SUMMARY A 66-year-old HIV/HCV co-infected female patient presented with painless,nonpruritic rash of extremities for one week and underwent extensive work-up for possible rheumatologic disorders including vasculitis and *** skin biopsies of right and left thigh revealed thickened parakeratotic stratum corneum most consistent with *** was started on prednisone and zinc supplementation with resolution of the lesions and improvement of *** Clinicians should maintain high clinical suspicion for early recognition of NAE in patients with rash and HCV.