Feed conversion ratio,residual feed intake and cholecystokinin type A receptor gene polymorphisms are associated with feed intake and average daily gain in a Chinese local chicken population

作     者：Zhenhua Yi Xing Li Wen Luo Zhenqiang Xu Congliang Ji Yan Zhang Qinghua Nie Dexiang Zhang Xiquan Zhang 

作者机构：Department of Animal GeneticsBreeding and ReproductionCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642GuangdongChina Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Laboratory of Chicken GeneticsBreeding and ReproductionMinistry of AgricultureGuangzhou 510642GuangdongChina Wen’s Nanfang Poultry Breeding Co.LtdYunfu 527400GuangdongChina 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2018年第9卷第4期

页      面：794-802页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 09[农学] 0906[农学-兽医学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：financial support from the High Technology Research and Development Program of China (2013AA102501) the National Key Technology Research and Development Program (2014BAD08B08) the China Agriculture Research System (CARS-41-G03,CARS-41-Z17) 

主　　题：CCKAR Chicken FCR RFI SNP 

摘      要：Background: The feed conversion ratio(FCR) and residual feed intake(RFI) are common indexes in measuring feed efficiency for livestock. RFI is a feed intake adjusted for requirements for maintenance and production so these two traits are related. Similarly, FCR is related to feed intake and weight gain because it is their ratio. Cholecystokinin type A receptor(CCKAR) plays an important role in animal digestive process. We examined the interplay of these three parameters in a local Chinese chicken population.Results: The feed intake(FI) and body weights(BW) of 1,841 individuals were monitored on a daily basis from 56 to 105 d of age. There was a strong correlation between RFI and average daily feed intake(ADFI) and a negative correlation between the FCR and daily gain(r_g=-0.710). Furthermore, we identified 51 single nucleotide polymorphisms(SNPs) in the CCKAR and 4 of these resulted in amino acid mutations. The C334A mutation was specifically associated with FI and the expected feed intake(EFI)(P 0.01) and significantly associated with the average daily gain(ADG)(P 0.05). G1290A was significantly associated with FI and EFI(P 0.05).Conclusion: FCR is apply to weight selecting, and RFI is more appropriate if the breeding focus is feed intake. And C334A and G1290A of the CCKAR gene can be deemed as candidate markers for feed intake and weight gain.