Preparation and in vitro Release of Donepezil Hydrochloride Microspheres
Preparation and in vitro Release of Donepezil Hydrochloride Microspheres作者机构：School of PharmacyJining Medicinal College
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2018年第9卷第6期
页 面：65-67页
学科分类：10[医学]
基 金：Supported by National Innovative Training Program for College Students(201610443020)
主 题：Donepezil hydrochloride Polylactic acid-glycolic acid copolymer Microsphere
摘 要：[Objectives]To prepare donepezil hydrochloride microspheres and evaluate their quality.[Methods]The donepezil hydrochloride microspheres were prepared by emulsification-solvent evaporation *** morphology was observed by scanning electron microscopy and the particle size distribution was determined by Laser Diffraction *** encapsulation efficiency,drug loading capacity,and in vitro release were determined by HPLC.[Results]The prepared donepezil hydrochloride microspheres were spherical with the average particle diameter of 15.927 μ*** drug loading capacity was 35.62%.The encapsulation efficiency was 90.32%.The drug release in vitro lasted for14 *** release curve accorded with the first-order kinetic equation.[Conclusions]The prepared donepezil hydrochloride microspheres performed good sustained release effect in vitro,and it was expected to be used for research on Parkinson s disease.
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