A NEW ANIMAL MODEL OF ERYTHROCYTE SENESCENCE: THE ALTERRATION OF SURFACE CHARGE AND THE RHEOLOGGICAL PROPERTIES OF ERRYTHROCYTE DRUING ITS LIFE SPAN

作     者：Wen Zongyao Song Lichua Lu Zhihong Sun Dagong(Department of Medical Physics, Beijing Medical University, Beijing 100083,China) Yan Zongyi(Department of Mechanics and Engineering SciencePeking University,Beijing 100871,China) Don Huanfu(Department of H 

出 版 物：《Chinese Journal of Biomedical Engineering(English Edition)》 (中国生物医学工程学报（英文版）)

年 卷 期：1998年第7卷第2期

页      面：75-86页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

主　　题：erythrocyte senescence surface charge rheological properties 

摘      要：Based on Mohandas＇ work, a new animal model of red blood cell(RBC) synchronous senescence in a near normal physiological conditions was proposed. Using this model,we studied the changes of RBC surface charge with the aging process. The results showed that its surface charge decreased with RBC agingprocess. Nevertheless,the regulation of the changes was not linear during RBC aging. The indexes of (DI)d and (DI)or describing RBC rheological behaviours duringits aging process were measured with a new Ektacytometry. It is demonstrated thatboth the indexes decreased with RBC aging,but the relationship was not linear. Thecharacteristics of the indexes displayed a common regularity of smaller alterationsin the first half period of RBC life span and greater alterations in the latter periodof RBC life span. It was also shown that the regulation of the changes for each individual index were not alike. The alterations of RBC mechanical properties duringlife span maight result from the influence of RBC shape, the properties of cytoplasm and membrane viscoelasity and the other factors during RBC aging.