Autonomic mechanism for chronic atrial electrical remodeling induced by rapid atrial pacing in ambulatory danines

作     者：YU Tao~1,WU Ruo-bin~1,GUO Hui-ming~1,DENG Hai~2,DENG Chun-yu~2,YU Xi-yong~2,QI Zhou-cuo~2,YAO Li-ming~2, KUANG Su-juan~2,LIN Qiu-xiong~2 (1.Department of Cardiac Sugery,Guangdong Cardiovascular Institute,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China 2.Guangdong Cardiovascular Institute,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510080,China) 

出 版 物：《岭南心血管病杂志》 (South China Journal of Cardiovascular Diseases)

年 卷 期：2011年第17卷第S1期

页      面：187-188页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Autonomic mechanism for chronic atrial electrical remodeling induced by rapid atrial pacing in ambulatory danines 

摘      要：Objetives The mechanism for changes in the electrophysiological properties of the atria during rapid pacing induced atrial fibrillation(AF) is not well *** aimed to investigate the contribution of intrinsic cardiac autonomic nervous system(ICANS) in chronic atrial electrical remodeling and AF induced by rapid atrial pacing for 4 weeks. Methods Twelve adult mongrel dogs weighing 15 to 20 kg were assigned to two groups;group 1(experimental group,n= 7) and group 2(control group,n =5).All dogs were anesthetized with propofol and mechanically ventilated via endotracheal *** chest was entered via bilateral mini-thoracotomy at the fourth intercostals *** pacing electrode was sutured to the right atrial ***-electrode catheters(Biosense-Webster,Diamond Bar,CA) were secured to allow recording at the right and left *** tracings from the electrode catheters were amplified and digitally recorded using a computer-based Bard Laboratory System (CR Bard Inc,Billerica,MA).Electrograms were filtered at 50 to 500 *** rapid pacing(600 bpm, 2×threshold[TH]) was performed at the right atrial appendage. Ganglionated Plexi(GP) was localized by applying high frequency stimulation(HFS;20 Hz,0.1ms duration, 0.5 to 4.5 V)with a bipolar stimulation-ablation probe electrode (AtriCure,West Chester,OH).Group1 underwent ablation of bilateral GP and ligament of Marshall followed by 4-week *** 2 underwent sham operaton without ablation of GP and ligament of Marshall followed by 4-week *** effective refractory period(ERP) and window of vulnerability(WOV) were measured at 2×TH before(baseline) and every week after GP *** was defined as the difference between the longest and the shortest coupling interval of the premature stimulus that induced *** consist of the anterior right ganglionated plexi(ARGP) located in the fat pad at the right superior pulmonary vein(RSPV)-atrial junction;the inferior right ganglionated plexi(IRGP