Cell Adhesion Inhibition by RGD Peptides Linked with a Photoisomerizable Nonnatural Amino Acid

作     者：张海黔 篠原宽明 顾宁 佐々木裕司 宍户昌彦 Zhang Haiqian;Shinohara Hiroaki;Gu Ning;Sasaki Hiroshi;Sisido Masahiko

作者机构：吴健雄实验室东南大学南京210096 生物科学与技术系冈山大学 

出 版 物：《Journal of Southeast University(English Edition)》 (东南大学学报（英文版）)

年 卷 期：2001年第17卷第2期

页      面：22-26页

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

主　　题：nonnatural amino acid cell adhesion photoisomerization integrin peptide 

摘      要：RGD peptides linked with a nonnatural amino acid, phenylazophenyl alaninine (azoAla), were synthesized and applied to cell adhesion inhibitors. The RGD peptides linked with azoAla at C terminal showed potent binding to the integrin on the surface of HeLa cells. Photoisomerization effect of the azobenzene side chain of synthesized peptides on the cell adhesion inhibition was further investigated. It was demonstrated that the cis form of azoAla linked RGD peptides revealed a little weak cell adhesion inhibition effect as compared with trans form of azoAla linked RGD peptide. 