Cholelithiasis in Children with Sickle Cell Anaemia: A Cross-Sectional Analysis from Northeast Nigeria

作     者：Ayomikun Ajani Iliya Jalo Suleiman Tanimu Saad 

作者机构：Department of Paediatrics Federal Teaching Hospital (FTH) Gombe Nigeria Department of Paediatrics College of Medical Sciences Gombe State University Gombe Nigeria Department of Radiology Federal Teaching Hospital (FTH) Gombe Nigeria 

出 版 物：《Open Journal of Pediatrics》 (儿科学期刊（英文）)

年 卷 期：2019年第9卷第1期

页      面：75-88页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Children Sickle Cell Anaemia Cholelithiasis Northeast Nigeria Adolescence 

摘      要：Background: Nigeria contributes 30% to the global sickle cell anaemia burden. Cholelithiasis occurs commonly in children with sickle cell anaemia and may remain undiagnosed, mimic abdominal vaso-occlusive crises or become complicated by calculus cholecystitis. Early identification of children with sickle cell anaemia who have Cholelithiasis reduces the chances of misdiagnosis, mistreatment and improves outcomes. There is limited knowledge about the prevalence of Cholelithiasis among Nigerian children with sickle cell anaemia. The present study aimed to determine the prevalence of Cholelithiasis in children with sickle cell anaemia in Gombe, northeast Nigeria. Methodology: This was a cross-sectional analysis of children with sickle cell anaemia being followed-up at the sickle cell centre of the Federal Teaching Hospital, Gombe, northeast Nigeria. We consecutively recruited 294 children aged 2 - 17 years while in steady state from June to November 2017. Quantitative data were collected from parents/caregivers via a researcher administered questionnaire and cholecystosonography performed after a minimum of 8-hour fast. Predictors of Cholelithiasis were examined using binary logistic regression. Results: The mean age of children with sickle cell anaemia was 9.0 ± 4.5 years. The prevalence of Cholelithiasis in children with sickle cell anaemia in steady state was 4.8%. Children aged 15 - 17 years had 12 times higher odds of having Cholelithiasis [AOR = 12.268 (95% CI = 1.3 - 112.8)]. Conclusion: The prevalence of Cholelithiasis in children with sickle cell anaemia though generally low, increases progressively with age to peak during middle to late adolescence.