The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval

作     者：Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang 

作者机构：Department of NeurologyAffiliated ZhongDa HospitalInstitute of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjing 210009China Shenzhen Key Lab of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain ScienceChinese Academy of Sciences (CAS) Center for Excellence in Brain Science and Intelligence Technologythe Brain Cognition and Brain Disease Institute for Collaboration Research of the Shenzhen Institutes of Advanced Technology at the CAS and the McGovern Institute at Massachusetts Institute of TechnologyShenzhen 518055China Department of BiophysicsMedical College of WisconsinMilwaukeeWI53226USA 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2019年第35卷第3期

页      面：447-460页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by the National Major Science and Technology Program of China(2016YFC1306700) the National Natural Science Foundation of China(81420108012,81671046,81425010 and 31630031) the Jiangsu Provincial Medical Program for Distinguished Scholars(2016006) Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX18_0167),China 

主　　题：Spatial memory Postrhinal cortex Ventrolateral orbitofrontal cortex Mild cognitive impairment Alzheimer's disease 

摘      要：A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in *** the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD.