Total pancreatic necrosis after organophosphate intoxication

作     者：Rui Hou Hongmin Zhang Huan Chen Yuankai Zhou Yun Long Dawei Liu 

作者机构：Department of SurgeryPeking Union Medical College Hospital (PUMCH)Chinese Academy of Medical SciencesBeijing 100730China Department of Critical Care MedicinePeking Union Medical College Hospital (PUMCH)Chinese Academy of Medical SciencesBeijing 100730China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2019年第13卷第2期

页      面：285-288页

核心收录：

学科分类：10[医学] 

主　　题：organophosphate intoxication severe acute pancreatitis pancreas necrosis percutaneous catheterization sandostatin insulin 

摘      要：Cases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides;she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodide. She received percutaneous catheterization and drainage of pancreatic zone to expel hazardous necrotic waste, also by which the pathogenic evidence was obtained and the antibiotics were adjusted subsequently. The patient recovered gradually, was discharged after 2 weeks, and was prescribed with oral pancreatin capsules before meals and hypodermic insulin at meals and bedtime to compensate the impaired pancreatic function.