Clinical features of seizures after cerebral venous sinus thrombosis and its effect on outcome among Chinese Han population

作     者：Hongyan Ding Yanan Xie Linxin Li Heling Chu Yuping Tang Qiang Dong Mei Cui 

作者机构：Department of NeurologyHuashan HospitalState Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina Nuffield Department of Clincial NeurosciencesJohn Radcliffe HospitalOxfordUK 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2017年第2卷第4期

页      面：184-188页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：seizures cerebral thrombosis 

摘      要：background and purpose Clinical features of epileptic seizures after cerebral venous sinus thrombosis(CVST)among Chinese patients are not known,and it is still controversial whether seizures would affect the outcome of *** In a Chinese hospital-based study of consecutive patients with CVST between 2003 and 2015,we described the clinical features of seizures and determined the predictors of seizure onset using multivariable logistic regression *** also compared the in-hospital case-fatality and short-term functional outcome(modified Rankin Scale(mRS)at discharge)in patients with versus without seizures using ordinal regression *** Among 151 patients with CVST,52(34.4%)presented seizures,of which 42(80.8%)were generalised *** gender(OR 6.32,95% CI 2.06 to 19.35,p=0.001),motor deficits(OR 4.89,95% CI 1.52 to 15.68,p=0.008),intracerebral haemorrhage(OR 3.93,95% CI 1.16 to 13.26,p=0.027),cerebral infarction(OR 3.78,95% CI 1.15 to 12.36,p=0.029)and superior sagittal sinus thrombosis(OR 3.38,95% CI 91.16 to 9.86,p=0.026)were independent predictors for *** overall in-hospital case-fatality rate was 2.0%(3/151),and 21(13.9%)had mRS2 at *** with patients without seizures,patients with seizures were more likely to have a worse outcome(p=0.02)at discharge,independent of age,gender,clinical presentation,clot burden and presence of parenchymal *** In Chinese Han patients,compared with patients without seizures,patients with seizures after CVST had a worse *** factors such as male gender,paresis,parenchymal lesion and superior sagittal sinus thrombosis were independently associated with seizure onset after *** seizure was the main form of seizures after CVST,which was obviously different to seizures after strokes of arterial origin.