The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome

作     者：Tiebing Zhu Jun Wang Leming Fan Yong Li Zhijian Yang Kejiang CAO Jun Huang 

作者机构：Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Atherosclerotic Reaserch Center of Nanjing Medical University Nanjing 210029 China 

出 版 物：《Journal of Nanjing Medical University》 (南京医科大学学报（英文版）)

年 卷 期：2006年第20卷第5期

页      面：271-274页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Education Department of Jiangsu Province(01KJB32006) 

主　　题：acute coronary syndrome TFPI polymorphism plasma 

摘      要：Objective： To investigate V264M polymorphism of tissue factor pathway inhibitor （TFPI） in patients with acute coronary syndrome （ACS） in Chinese. Methods ： The genotypes of V264M were detected by polymerase chain reaction （PCR） and restriction fragment length polymorphism （PCR-RFLP） in 136 patients with ACS and 106 healthy controls with their plasmal f-TFPI tested by enzyme linked immunosorbent assay （ELISA）. Results： Two genotypes were found in V264M： GG and GA. The distribution frequencies of alleles and genotypes were in accordance with those predicted by Hardy Weinberg equilibrium in the present study （χ2 = 0.437, P 〉 0.05）. Plasma f-TFPI level was lower in A allele bearer than that in non-A allele carriers and higher in ACS than control subjects （P〈0.05）. No relationship was found between ACS and V264M polymorphism （P〉0.05）. Conclusion： The V264M polymorphism may have an impact on the plasma level of free TFPI（f-TFPI）, but it has no relationship with ACS.