Enterocytes’tight junctions:From molecules to diseases

作     者：Stelios F Assimakopoulos Ismini Papageorgiou Aristidis Charonis 

作者机构：Department of Internal MedicineUniversity Hospital of PatrasPatras 26504Greece Institute of Physiology and PathophysiologyRuprecht-Karls University of Heidelberg69120 HeidelbergGermany Biomedical Research Foundation of the Academy of AthensAthens 11527Greece 

出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第6期

页      面：123-137页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：Tight junctions Occludin Claudins Junc- tional adhesion molecule Tricellulin Intestinal permeability 

摘      要：Tight junctions(TJs)are structures between cells where cells appear in the closest possible *** are responsible for sealing compartments when epithelial sheets are *** regulate the permeability of ions,(macro)molecules and cells via the paracellular *** structure at the electron microscopic level has been well known since the 1970s;however,only recently has their macromolecular composition been *** review first examines the major macromolecular components of the TJs(occludin,claudins,junctional adhesion molecule and tricellulin)and then the associated macromolecules at the intracellular plaque[zonula occludens(ZO)-1,ZO-2,ZO-3,AF-6,cingulin,7H6].Emphasis is given to their interactions in order to begin to understand the mode of assembly of *** functional significance of TJs is detailed and several mechanisms and factors involved are discussed *** is given to the role of intestinal TJs and the alterations observed or speculated in diverse disease ***,intestinal TJs may exert a pathogenetic role in intestinal(inflammatory bowel disease,celiac disease)and extraintestinal diseases (diabetes type 1,food allergies,autoimmune diseases).Additionally,intestinal TJs may be secondarily disrupted during the course of diverse diseases,subsequently allowing the bacterial translocation phenomenon and promoting the systemic inflammatory response,which is often associated with clinical *** major questions in the field are highlighted.