Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing

作     者：YAN Shuai YUE Yin-zi ZONG Yang ZENG Li 

作者机构：Department of Anorectal Surgery Suzhou Hospital of Traditional Chinese Medicine Suzhou (215009) Jiangsu Province China First College of Clinical Medicine Nanjing University of Chinese Medicine Nanjing (210023) China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2019年第25卷第7期

页      面：554-560页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(No.81804098,81673982) Natural Science Foundation of Jiangsu Province(No.BK20180219) Young Talents in Jiangsu Province(No.QNRC2016255) Youth Project of Suzhou Traditional Chinese Medicine Hospital(No.YQN2016003) 

主　　题：tetramethylpyrazine tissue adhesion pharmacological activity review 

摘      要：Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine(TMP), one of the most widely used medicinal compound isolated from traditional Chinese herb, is usually employed for anti-oxidation, anti-inflammation, anti-platelet aggregation, antilipid, anti-fibrosis, as well as activating blood, removing stasis, dilating small arteries, improving microcirculation and antagonizing calcium. In the present paper, the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on in vitro experiments and animal experiments, there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material.