Emerging pathways of communication between the heart and non-cardiac organs

作     者：Eugenio Hardy-Rando Carlos Fernandez-Patron 

作者机构：Biotechnology LaboratoryStudy Center for Research and Biological EvaluationsInstitute of Pharmacy and FoodsUniversity of Havana Department ofBiochemistryCardiovascular Research CentreMazankowski Alberta Heart InstituteFaculty of Medicine and DentistryUniversity of Alberta 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2019年第33卷第3期

页      面：145-155页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by a Natural Sciences and Engineering Council of Canada Discovery Grant funding from the University of Alberta Hospital Foundation for Medical Research Visiting Scientist Fund from University of Alberta International 

主　　题：heart liver metabolism inflammation natriuretic peptides microRNA matrix metalloproteinase 

摘      要：The breakthrough discovery of cardiac natriuretic peptides provided the first direct demonstration of the connection between the heart and the kidneys for the maintenance of sodium and volume homeostasis in health and disease. Yet,little is still known about how the heart and other organs cross-talk. Here, we review three physiological mechanisms of communication linking the heart to other organs through: i) cardiac natriuretic peptides, ii) the microRNA-208 a/mediator complex subunit-13 axis and iii) the matrix metalloproteinase-2(MMP-2)/C-C motif chemokine ligand-7/cardiac secreted phospholipase A2(sPLA2) axis-a pathway which likely applies to the many cytokines, which are cleaved and regulated by MMP-2. We also suggest experimental strategies to answer still open questions on the latter pathway. In short, we review evidence showing how the cardiac secretome influences the metabolic and inflammatory status of non-cardiac organs as well as the heart.